摘要
目的 探讨急性心肌梗死 (AMI)患者可溶性的白介素 6受体水平变化与心功能的关系。方法 用酶联免疫吸附法检测AMI患者 (AMI组 ) 2 2例 ,稳定性心绞痛患者 (SA组 ) 33例的血清可溶性白介素 6受体(sIL 6R)水平变化 ,并与 30例健康对照者 (对照组 )比较。结果 ①AMI组血清sIL 6R水平明显高于SA组 (P <0 .0 5 )及对照组 (P <0 .0 1) ,且随心功能恶化而逐渐升高 ,KillipⅡ～Ⅳ级各亚组间差异有非常显著意义 (P <0 .0 1)。②sIL 6R水平与左室射血分数呈显著负相关 (r=- 0 .78,P <0 .0 1)。结论 sIL 6R水平可作为AMI诊断的实验指标 ,结果提示sIL 6R参与了心梗的发生。
Objective To explore the relation between the serum level of soluble interleukin 6 receptor(sIL 6R) and cardiac function in patients with acute myocardial infarction(AMI).Methods Serum levels of sIL 6R in 22 patients with AMI (AMI group ) and 18 patients with stable angina(SA group) were examined with enzyme linked immunosorbent assay(ELISA) and data were compared with control group of 30 age matched healthy subjects.Results ①Serum levels of sIL 6R were significantly higher in patients with AMI than those with SA(P<0.05) and controls (P<0.01).More specifically,they were progressively elevated with severity of cardiac function and there were significant differences in subgroups of Killip Ⅱ～Ⅳ(P<0.01).②The sIL 6R levels were inversely related to LVEF(r=-0.78,P<0.01).Conclusion The serum level of sIL 6R can serve as experimental parameter for diagnosis of AMI,which suggests that sIL 6R may be involved in pathogenesis of AMI.
出处
《潍坊医学院学报》
2003年第2期136-137,共2页
Acta Academiae Medicinae Weifang
