1994～2001年抑郁症首发住院患者的治疗药物分析

A Study of Changes of Medication of First Episode of Depressive Inpatients from 1994～2001

目的 :探讨 1994～ 2 0 0 1年抑郁症首发患者住院期间选用治疗药物的变化规律。方法 :应用自制调查表回顾近 8年 338例抑郁首次发作患者住院期间的临床用药、疗效、不良反应以及联合用药特点。结果 :各种抗抑郁药 ,包括三环类、四环类、单胺氧化酶、SSRI类和其他新一代抗抑郁药对抑郁症的疗效基本相似 ,而新一代抗抑郁药因为较轻或较少的药物不良反应 ,临床应用将会日益增加 ,传统药物的应用将会逐渐减少 ,单一用药的疗效仍不能完全满足临床需要 ,部分患者仍需要联合用药。结论 :新一代抗抑郁药和新一代抗精神病药物利培酮等将更多应用于抑郁症治疗以及伴有精神病症状的抑郁症患者的治疗。

Objective: To investigate the medication change in the first episode of depressive patients in hospital from 1994～2001.Mehtod: 338 first episode depressive inpatients and their medication were reviewed and the medical effects, side effects and combining medication were compared with self-making questionnaire.Result: All antidepressants had a similar therapeutic effect, including tricyclic antidepressants, tetracyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitor and other new antidepressants. But the new antidepressants would apply to clinic increasingly for fewer side effects; meanwhile the classical antidepressants were gradually decreased. Monotherapy with antidepressants was not completely satisfactory. Part of the patients still needed more than one medication.Conclusion: New antidepressants and new antipsycholics will be more and more used to treat depressive patients and patients who are accompanied with psychotic symptoms.