对氯苯基丙酮的合成

A New Process for 4-Chlorophenylacetone Synthesis

以对氯氯苄为主要原料,以四氢呋喃为溶剂,研究了药物中间体对氯苯基丙酮的合成新工艺。工艺由对氯苄基氯化锌的合成和对氯苯基丙酮的合成反应组成,优化的工艺条件为:对氯氯苄、锌粉及乙酐的物质的量之比是1∶1.2∶2.5;对氯苄基氯化锌的合成温度60～65℃,反应时间3h;对氯苯基丙酮合成温度30～35℃,反应时间5h。最终产物总收率78%。

A new process for the synthesis of 4chlorophenylacetone from organic zinc reagent and acetic anhydride was studied. The optimized conditions were determined by experiments as followed: the mass ratio of 1∶1.2∶2.5, the reaction temperature of 60-65 ℃ for 4chlorobenzyl zinc chlorides for 3 hours, and the reaction temperature of 30-35 ℃ for 4chlorophenylacetone for 5 hours. The yield rate of 4chlorophenyacetone was 78%.