鲁米诺-铁氰化钾化学发光体系测定氯丙嗪

Luminol-Ferricyanide Flow Injection Chemiluminescence Method for Determination of Chlorpromazine

在碱性条件下,铁氰化钾氧化鲁米诺产生化学发光,氯丙嗪对该体系的化学发光有显著的增强作用.基于此,结合流动注射技术建立了测定氯丙嗪的化学发光新方法.该方法有很高的灵敏度,检测限为5 7×10-9g/mL(IUPAC),线性范围为1 0×10-8～1 0×10-6g/mL,对1 0×10-7g/mL氯丙嗪平行测定11次,其相对标准偏差为2 7%.

A flow injection chemiluminescence (FICL) method for the determination of chlorpromazine based on the enhancement of its on the chemiluminescence from luminolferricyanide system is investigated. The concentration range of linear response is 10×10-8-10×10-6 g/mL. The detection limit is 57×10-9 g/mL with a relative standard deviation of 27% for the determination of 10×10-7 g/mL of chlorpromazine (n=11). The proposed method with simplicity, rapidity and sensitivity has been successfully applied to the determination of chlorpromazine in pharmaceutical preparations.