穿琥宁肠溶胶囊在犬体内的药物动力学及绝对生物利用度

Pharmacokinetics and bioavailability of Kalii Dehydrograpolidi Succinatis Enteric capsules in plasma of dog

目的 研究穿琥宁肠溶胶囊在犬体内的药物动力学及绝对生物利用度。方法 家犬 6只 ,随机分为 2组 ,采用单剂量交叉给药方案 ,分别给犬单剂量静脉注射或口服穿琥宁肠溶胶囊 ,用HPLC法测定给药后的血中药物浓度 ,3p97药动学程序处理。结果 穿琥宁肠溶胶囊的药 -时数据符合二室模型 ,Cmax为 2 4 .3μg·ml-1,Tmax为 1.2 6h ,AUC(0→∞ ) 为 2 92 84 μg·ml-1,绝对生物利用度为 30 .0 3%。

OBJECTIVE To study the pharmacokinetics and bioavailability of Kalii Dehydrograpolidi Succinatis Enteric capsules in plasma of dog.METHODS A single dose of Kalii Dehydrograpolidi Succinatis were iv or orally given to 6 dogs in an open randomized crossover test. HPLC was selected to determine the concentration of Kalii Dehydrograpolidi Succinatis in serum. The pharmacokinetic parameters of Kalii Dehydrograpolidi Succinatis enteric capsules was calculated and analysed by 3p97 program.RESULTS The disposition was conformed to a two-compartment model.The T max , C max , AUC 0→∞ and Absolut bioavailability of Kalii Dehydrograpolidi Succinatis enteric capsules were 24.3 μg·ml -1 ,1.26 h ,29284 μg·ml -1 ·h and 30.03%.CONCLUSION Kalii Dehydrograpolidi Succinatis enteric capsules has a good bioavailability.