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4-苯甲氧基苯乙酸的合成方法改进

An improved synthesis of 4-phenylmethoxy phenylacetic acid
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摘要 目的 改进 4 -苯甲氧基苯乙酸的合成方法。方法 以对羟基苯乙酸为原料 ,经一步反应制得目标产物。结果 所得目标化合物质量与文献一致 ,收率达 90 %。结论 新的合成方法时间短 ,后处理简便 ,收率高 。 OBJECTIVE To improve the synthesis route of 4-phenylmethoxy benzeneacetic acid.METHODS With 4-hydroxy phenylacetic acid as the material, the target product is obtained by one step.RESULTS The recovery was 90%.CONCLUSION The new method has a shorter reaction time, higher yield and can be used for large scale preparation.
作者 侯华 翁玲玲
出处 《华西药学杂志》 CAS CSCD 2003年第2期116-117,共2页 West China Journal of Pharmaceutical Sciences
关键词 4-苯甲氧基苯乙酸 合成方法 4-羟基苯乙酸 PH值 Phenylmethoxy phenylacetic acid Derivatives Synthesis
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参考文献3

  • 1Kuchar M,Rejholec V,Roubal Z,et al.The effect of lipophilicity on the inhibition of denaturation of serum albumin and on the activation of fibrinolysis observed with a series of benzyloxyarylaliphatic acids[].Collection of Czechoslovak Chemical Communications.1983
  • 2Mannekens E,Tourwe D,Lubell WD.Efficient synthesis of 1- Benyloxyphenyl-3- phenylacetones[].Synthesis.2000
  • 3Todashige C,Toshifumi A,Motomi M,et al.Total synthesis of Spidamine and Joramine, polyamine toxins from the joro spider, Nephila Clavata[].Chemical and Pharmaceutical Bulletin.1996

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