药物致急性肾衰竭31例临床分析

Clinical analysis of 31 cases with acute renal failure caused by drugs

目的 了解不同药物肾损害的临床表现、病理改变和预后 ,提高药物性肾损害的诊治水平。方法 回顾性分析 3 1例药物性急性肾衰竭的致病药物、临床表现、病理改变、治疗结果和预后。结果 引起肾损害的主要药物为氨基糖甙类 ( 9例 ,2 9% )、头孢菌素类 ( 6例 ,19% )和非甾体类抗炎药 ( 6例 ,19% ) ,主要病理改变为间质性肾炎和 (或 )肾小管坏死 ,治愈率 97%。结论 肾活检是确诊的主要手段 。

Objective To comprehend the clinical,pathological feature and prognosis of drug renal injury and to improve its diagnosis and treatment level.Methods Thirty one cases with acute renal failure caused by drugs were retrospectively reviewed and their etiologies?clinical and pathological manifestations,treatment effects and prognosis were analyzed.Results Aminogiycosides(29%),cephalosporins(19%) and NSAIDs(19%) are the common drugs that result in renal injury.Acute tubule necrosis and/or interstitial nephritis can often be seen by renal biopsy.Cure rate is 97%.Conclusion Renal biopsy is the best means of definite diagnosis.Dialysis should be early preceded for those uremic patients.