妊高征患者红细胞免疫功能与脂质过氧化关系的研究

Study on the relationship between red blood cell immunity and lipid peroxidation in patients with pregnancy induced hypertension

目的 探讨妊高征患者红细胞免疫功能的变化及其与脂质过氧化的关系。方法 应用红细胞酵母花环法测定了 38例妊高征患者红细胞免疫功能和化学比色法测定血浆丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH- PX)含量 ,并与 35名正常孕妇对照。结果 妊高征患者 RBC- IC花环率和 MDA水平明显升高 (P<0 .0 1) ,而 RBC- C3b R、SOD、GSH- PX、SOD/ MDA低于正常 (P<0 .0 1) ,相关分析显示 :RBC- C3b花环与MDA呈显著的负相关 (r=- 0 .4 12 5 ,P<0 .0 5 ) ,RBC- ICR与 MDA呈正相关 (r=0 .6 2 84 ,P<0 .0 1)。结论 妊高征患者红细胞免疫粘附功能降低 ,与活性氧代谢紊乱密切相关。

Objective To study the red blood cell immunity and the relationship between red blood cell immunity and lipid peroxidation(Lpo) with pregnacy induced hypertension.Methods The red blood cell C 3b receptor(RBC C 3b R) and red blood cell immunl complex rosette(RBC ICR) were measured in 38 patients with pregnancy induced hypertenision and 35 normal controls and the levels of malondialdehyde(MDA),superoxidase(SOD) and glulathione peroxidase(GSH PX) were measured by chemocolorimetry.Results RBC ICR and MDA levels were significantly higher in patients with pregnancy induced hypertension than those in normal controls( P <0.01).While RBC C 3b R?SOD?GSH PX?SOD/MDA ratio were significantly lower in patients with pregnancy induced hypertension than those in normal controls( P <0.01).On the contrary,the content of MDA was significantly increased,RBC ICR was positively correlated with MDA.Conclusion The lower red cell immune adhesion function is closed associated with the lipid peroxidation disturbance in pregnancy induced hypertension.