兰山区麻疹疫苗强化免疫效果分析

Evaluation on the effect of intensive immunization of measles vaccine in Lanshan

目的 进一步控制兰山区的麻疹疫情。方法 1999年度对该区149 016名8月龄～14岁儿童实施了麻疹疫苗(MV)强化免疫,接种率为97.38％。随后开展了麻疹免疫监测,应用酶联免疫吸附法(ELISA)检测麻疹和风疹IgM抗体,微量血凝抑制试验检测麻疹IgG抗体。结果 强化免疫后麻疹抗体阳转率达100%,GMT从1:5.56上升到1:52.68;经过流行病学观察,强化免疫后麻疹疫情被控制,2 a后发病率下降到0.75/10万,麻疹发病数与1999年相比,下降了97.53％。检测79例麻疹疑似病例血清,其中麻疹IgM阳性16例,占20.25％;风疹IgM阳性12例,占15.19％。结论 开展麻疹强化免疫对控制麻疹效果非常显著。

[Objective]To improve measles control work in Lanshan. [Methods ]Intensive immunization on measles has been conducted on 8 months - 14 - year - old children in this area in 1999 and the immunization coverage rate of measles vaccine (MV) was 97.38 % . IgM antibody of measles was tested with ELISA and IgG antibody was examined with HI test. [ Results ] The positive rate of measles antibody among children was 100%, GMT increased from 1:5.56 to 1:52.68. The epidemiological observation shows that the measles was under control after the intensive immunization. The morbidity rate decreased by 97.53% compared with 1999, with only 0.75/100,000 two years after the vaccine taking. Among the 79 cases of suspected measles, 16 cases showed positive measles IgM (20.25% ), 12 cases showed positive rubella IgM (15.19% ) . [Conclusion]The intensive immunization of measles vaccine has significant effect on measles control.