2-烃基-2,2-二烯丙基乙酸类化合物的新法合成

A Novel Method for Preparing 2-Alkyl-2,2-diallylacetic Acids

以2位烃基取代乙酸为起始原料,与烯丙基氯反应成酯后,在氢化钠的催化作用下进行Claisen重排反应得到4-戊烯酸类化合物,再经酯化和Claisen重排反应得到2-烃基-2,2-二烯丙基乙酸类化合物,4步反应收率为15.4%～53.5%。

A novel and practical synthetic method for the preparation of 2alkyl2,2diallylacetic acids was reported. 2Alkyl4pentenioc acids was obtained by esterification of 2alkylacetic acids with allyl chloride and Claisen rearrangement catalyzed by sodium hydride. After esterification and Claisen rearrangement of 2alkyl4pentenioc acids, 2alkyl2,2diallylacetic acids was obtained in 15.4%～53.5% yield.