摘要
利用二水氯化铜、2 ,2′ 联吡啶和去甲基斑蝥酸钠合成了桥联配体双核铜配合物 [(bipy) (DCA)Cu (DCA) Cu(bipy) (H2 O) ]·3H2 O(式中bipy为 2 ,2′ 联吡啶 ,DCA为去甲基斑蝥酸根 ) .通过元素分析、红外光谱、紫外 -可见光谱和电导对其结构进行了表征 .用X射线单晶衍射测定了该配合物的晶体结构 .配合物经验分子式为Cu2 C3 6H40 N4O14 ,属三斜晶系 ,空间群P1- ,a =1 12 5 1( 2 )nm ,b =1 2 70 7( 3 )nm ,c =1 73 45 ( 4 )nm ,α =94 86( 3 )° ,β =10 7 61( 3 )° ,γ =112 5 0 ( 3 )° ,V =2 12 64 ( 7)nm3 ,μ =1 0 66mm-1,Z =2 ,Dc=1 3 74g/cm3 ,F( 0 0 0 ) =90 8,R =0 0 5 47,wR2 =0 13 5 5 ,GOF =0 815 .配合物中两个铜原子呈六配位的拉长畸变八面体构型 .
A bridging ligand compound [(bipy)(DCA)Cu (DCA) Cu(bipy))H 2O)]·3H 2O (bipy=2,2′ bipy^ridine, DCA=demethylcantharate) has been synthesized by copper chloride dihydrate, 2,2′ bipyridine and disodium demethylcantharate. The structure was characterized by elemental analysis, IR, UV spectra and conductance. The crystal structure was determined by X ray single crystal diffraction. The crystal having empirical formula Cu 2C 36 H 40 N 4 ~O 14 belongs to triclinic with space group P 1-, a =1 1251(2) nm, b =1 2707(3) nm, c =1 7345(4) nm, α =94 86(3) o, β =107 61(3) o, γ =112 50(3) o, V =2 1264(7) nm 3, μ =1 066 mm 1 , Z =2, D c =1 374 g/cm 3, F (000)=908, R =0 0547, wR 2=0 1355, GOF =0 815, in which the copper atoms are six coordinated in a stretched aberration octahedral geometry. The compound was tested in vitro against human tumor cell lines, HL 60, BGC 823, Bel 7402 and Hela, and displayed high activity.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2003年第4期556-561,共6页
Acta Chimica Sinica
基金
国家自然科学基金 (No.2 9571 0 0 7)