双核Cu(II)-牛磺酸缩水杨醛席夫碱配合物的合成、晶体结构及生物活性

Synthesis, Crystal Structure and Bioactivity of a Binuclear Copper(II) Complex

合成了双核铜配合物 [Cu(TSSB) (H2 O) ] 2 ·2H2 O (TSSB =牛磺酸缩水杨醛席夫碱 ) ,通过元素分析、红外光谱对配合物进行了表征 ,并利用X射线法测定其结构 .晶体属三斜晶系 ,空间群P1- ,其晶胞参数为 :a =0 .69613 ( 19)nm ,b =0 .93 0 7( 3 )nm ,c=1.0 43 9( 3 )nm ;α =10 8.796( 5 )° ,β =10 1.2 71( 5 )° ,γ =10 5 .617( 5 )° ,V =0 .5 869( 3 )nm3 ,Z =1,Dcald=1.849g/cm3 ,μ =2 .0 5 8mm-1,F( 0 0 0 ) =3 3 4,Gof =1.0 79,Δρ =3 79～ -4 0 6e·nm-3 .两个铜原子配位数各为五 ,处于变形四方锥的配位环境中 .并对配合物进行了的生物活性试验 ,结果表明 ,配合物抗菌活性与青霉素接近 ,肿瘤抑制率达 63 .5 % .半数致死量为 10 0 0mg/kg .有可能成为一种新的抗菌。

A binuclear copper(II) compound, [Cu(TSSB)(H 2O)] 2·2H 2O (TSSB=taurine salicylic schiff base) has been synthesized and characterized by IR, elemental analysis, and X ray diffraction method. Crystal data: triclinic system with space group P 1- and unite cell parameters: a =0.69613(19) nm, b =0.9307(3) nm, c = 1.0439(3) nm; α =108.796(5)°, β =101.271(5)°, γ =105.617(5)°, V =0.5869(3) nm 3, Z =1, D cald =1.849 g/cm 3 , μ =2.058 mm -1 , F (000)=334, Gof =1.079, Δ ρ =379～-406 e·nm -3 . In the molecule of the complex, two Cu(II) ions are all five coordinated with distorted square pyramid configuration. The complex has been tested for the bacteriostatic and anticancer activities which shows that the bacteriostatic activity of the complex is similar to that of penicillin, the maximal cancer inhibition is 63.5% with the anticancer activity similar to Ge M 10 and the LD 50 is 1000 mg/kg. The compound may become a potential medicine for anticancer and antibiosis uses.