肝豆状核变性合并脾功能亢进的外科治疗

Surgical treatment for Wilson’s disease accompanied by hypersplenia

目的 探讨肝豆状核变性合并脾功能亢进患者的治疗方法及脾切除术的适应证和禁忌证。方法 总结2 6例肝豆状核变性合并脾功能亢进行脾切除术患者资料 ,对其术前术后白细胞与血小板计数进行比较。结果 2 6例患者术后白细胞与血小板计数明显升高 (P <0 .0 0 1 ) ,并能继续进行驱铜治疗。

Objective It is to explore the surgical treatment on Wilson’s disease (WD) accompanied by hypersplenia and observe the adaptation and contraindication for splenectomy. Methods Splenectomy was performed in 26 patients with WD accompanied by hypersplenia. Their clinical data were summed up and the leucocyte and thrombocyte were compared between preoperation and postoperation. Results The leukocyte and thrombocyte increased significantly ( P <0.001) after splenectomy and the therapy of expelling cuprum might be carried on consequently. Conclusion Splenectomy can enhance the total clinical effect in WD.