摘要
目的 :考察白细胞介素 (rh IL - )预防肿瘤病人化疗所致的血小板减少症的疗效及安全性。方法 :采用自身交叉随机对照试验 ,其中 AB组 17例 ,BA组 15例。每组病人均化疗二个疗程。 A疗程化疗后加 rh IL - 治疗 ,5 0μg/(kg·d) ,于化疗结束后 2 4小时开始 ,臀部皮下注射 ,每天一次。连用 14天或直到血小板从最低点恢复至 >40 0× 10 9/L,B疗程仅接受化疗 ,同一病人两疗程的化疗方案和剂量相同。结果 :A疗程全组血小板平均数量 (15 5 .99± 43 .2 4× 10 9/L)较B疗程 12 0 .44± 3 9.49× 10 9/L)提高 (P<0 .0 1) ,A疗程血小板最高值 (2 3 3 .3 4± 72 .74× 10 9/L )较 B疗程 (15 9.0 9± 49.15× 10 9/L )提高 (P<0 .0 1)。结论 :rh IL - 对化疗引起的血小板减少症有预防作用 。
Objective:To evaluate the efficacy and safety of Interleukin Elevn(IL -Ⅱ)in prevention of thrombocytopenia cased by chemotherapy Methods:A randomized,self-controlled,cross-over study,17 patient for AB group, and 15 patien ts for BA group Each group got same dhemoterapy for two cycles For Acycle,RhIL-Ⅱ wa s added for treatment after chemotherapy,but B cycle was not,then compared the c h ange of the number of platelet of the two cycles Dosing began 24h following the completion of chemotherapy,rhIL-Ⅱ of 50ug/kg daily subcutaneous dosing for 14 d a ys,or until the number of platelet increaed to the level of >400 10 9/L from t he na dirs Results:A cycle show better than B cycle in the average number of platelet (155 99±53 24×10 9/L vs 159 09±49 15×10 9/L, P <0 01).Conclu sions:Interleukin Eleven (IL-Ⅱ) is effective in prevention of thrombocytopenia caused by chemotherqpy I t is an effective and safe drug to treat platelet induce
出处
《现代预防医学》
CAS
2003年第2期184-184,共1页
Modern Preventive Medicine
