葛根素与甲钴胺联合治疗糖尿病周围神经病变的疗效观察

Observation on Effects of Karonein Combined with Mecobalamin Treating Diabetic Peripheral Neuropathies

目的 评价葛根素与甲钴胺联合应用对糖尿病周围神经病变的疗效。方法 79例糖尿病周围神经病变患者随机分组 ,治疗组 47例 ,给予葛根素氯化钠注射液 [4 0 0mg/( 2 5 0ml·瓶 ) ] ,静脉点滴 ,qd ,同时服用甲钴胺 5 0 0 μg ,tid ,共 4周 ;对照组 3 2例 ,单服甲钴胺 5 0 0 μg ,tid ,共 4周。 结果 治疗组痛觉过敏及感觉减退有效率达 65 .6%和 65 .5 % ,明显高于对照组的 3 5 .0 %和 47.8% (P <0 .0 5 ) ;神经传导速度改善的有效率明显提高 (P <0 .0 1)。治疗组空腹血糖、糖化血红蛋白、红细胞山梨醇显著下降 ,而对照组无显著差异。结论 葛根素与甲钴胺联合应用可明显改善对糖尿病周围神经病变的治疗效果。

Objective To evaluate the effect of karonein combined with mecobalamin on diabetic neuropathies.Method 79 patients with diabetic neuropathies were randomly divided into two groups.In treatment group(n=47),the patients were treated with karonein(400mg/d,iv) and mecobalamin(500μg/8h,po) for 4 weeks.In control group(n=32),the patients were treated with mecobalamin(500μg/8h,po) for 4 weeks.Results The percentages of hyperaolgia and hypoesthosia improvement were 65.6% and 65.5% respectively in treatment group,which were significantly higher than those in control group(35.0% and 47.8%, P <0.05).The velocity of nerve conduction in treatment group increased significantly( P <0.01).The serum levels of FBG,HbA1c,and erythrocyte polyol decreased markedly in treatment group,whereas no appearent changes were found in control group.Conclusion Combined administration of karonein and mecobalamin could significantly improve the therapeutic effect on diabetic neuropathies.