咸虾花化学成分的研究

Studies on the Constituents from the Herb of Vernonia patula

目的 :分离鉴定斑鸠菊属植物咸虾花中的化学成分 ,为PC 12细胞生长促进剂的筛选提供样品。方法 :90 %乙醇提取 ,硅胶柱色谱分离 ,用IR ,NMR和MS等方法确定结构。结果 :分得并鉴定了 4个三萜化合物 ,分别为降香萜醇乙酸酯 (bauerenylacetate,I) ,无羁萜酮 (friedelin ,Ⅱ ) ,表无羁萜醇 (epifriedelanol,Ⅲ ) ,2 0 (30 ) 蒲公英烯 3β ,2 1α 二醇 [2 0 (30 ) taraxastene 3β ,2 1α diol,Ⅳ ]。结论 :化合物I和Ⅳ为首次从斑鸠菊属植物中分得 ,化合物Ⅱ和Ⅲ为首次从咸虾花中分离得到。活性测试表明 ,这 4个化合物对PC

Objective: To isolate and elucidate the chemical constituents of the whole plant of Vernonia patula , and to provide samples for biological activity screening. Method: The chromatography on silica gel was used and the structures were determined by IR, NMR and MS spectra analysis and physicochemical property comparion. Result: Four triterpenoids were isolated and identified as bauerenyl acetate(I), friedelin (Ⅱ), epifriedelanol (Ⅲ),20(30) taraxastene 3β,21α diol(Ⅳ). Conclusion: Compounds I and Ⅳ were isolated from genus Vernonia for the first time and compounds Ⅱ and Ⅲ were isolated from the whole plant of V. patula for the first time. The four compounds show no inhibitory effect on the growing of PC 12 cells.