雪胆提取物对实验性胃溃疡作用的研究

Studies on Effects of Xuedan on the Experimental Gastric Ulcer

目的 :研究雪胆提取物对实验性胃溃疡的保护作用及抗炎、镇痛、抑菌等作用。方法 :采用大鼠应激性胃溃疡、幽门结扎性胃溃疡、醋酸致胃溃疡等模型观察雪胆提取物抗胃溃疡作用 ;对正常大鼠胃液分泌的影响 ;小鼠耳廓肿胀抗炎试验 ,扭体法镇痛试验以及体外抑菌试验。结果 :雪胆提取物能使大鼠实验性胃溃疡的溃疡面积缩小、溃疡指数降低 ;能减少大鼠胃液分泌、降低胃酸度及胃蛋白酶活性 ;对幽门螺杆菌等有较好的抑菌和杀菌作用 ;抑制小鼠耳廓肿胀 ,减少扭体次数。结论

Objective:To study the protective effects of Xuedan on the experimental gastric ulcer and the effects of anti inflammatory, analgesic and bacteriostasis. Method: The anti gastric ulcer effects of Xuedan was investigated with gastric ulcer models induced by being immersed in cold water,having pylorus ligature and HAC injected into serous membrane in rats. The influence of gastric juice secrete in normal rats, the anti inflammation action resulted from auricle swelling in mice, the analgesic action by mice body torsion method and the bacteriostotic effect in vitro were observed. Result: Xuedan could reduce the ulcer area and decrease ulcer index,and gastric juice secrete. The hydrochloric acid in gastric juice and the activity of pepsin were reduced in rats. It could inhibit and disinfect Helicobacter pylori, lessen auricle swelling and the number of body torsion in mice. Conclusion: Xuedan obvious preventive and treating effects on experimental gastric ulcer.