细胞间黏附分子-1在甲状腺相关眼病泪腺组织中的表达及意义

Expression of intercellular adhesion molecule-1 in lacrimal glands derived from thyroid associated ophthalmopathy

目的 研究甲状腺相关眼病 (TAO)患者泪腺组织ICAM 1的表达。方法 运用免疫组化方法 ,对TAO患者和正常对照组各 2 0例泪腺组织石蜡切片进行光学显微镜观察。结果 TAO组泪腺上皮细胞、血管内皮细胞和淋巴细胞表达ICAM 1明显高于正常对照组。结论 泪腺上皮细胞可能是病变组织的靶细胞 。

ObjectiveTo investigate the expression of intercellular adhesion molecule 1(ICAM 1) in lacrimal glands of thyroid associated ophthalmopathy (TAO).MethodsUsing immunohistochemical methods,paraffin sections of lacrimal glands obtained from 20 patients with TAO and 20 normal controls were observed under the light microscope.ResultsThe expression of ICAM 1 was detected in lacrimal gland acinar epitheliums,vascular endothelia and lymphocytes.The expression of ICAM 1 in TAO was significantly higher compared with control group.ConclusionAcinar epithelial may be the target cells in lacrimal glands of TAO. Vascular endothelium and lymphocytes could be involved in the development of TAO.