沈阳农村60岁以上人群良性前列腺增生危险因素的病例对照研究

A case-control study on the risk factors of benign prostatic hyperplasia in the suburb of Shenyang

目的 探讨各种危险因素与良性前列腺增生 (BPH)的关系。方法 采用以人群为基础的病例对照研究 ,病例组为沈阳市某郊区农村 60周岁以上BPH患者 ,对照组为无前列腺增生 (排除前列腺癌、前列腺炎等疾病 )的老年男性 ,病例与对照各 1 0 0例 ,单因素分析采用 χ2 检验 ,多因素分析利用非条件logistic回归分析。结果 多因素非条件logistic回归分析显示BPH发病与下列 5种因素有关 :患前列腺炎 (OR =5 .577,95 %CI:2 .1 4 7～ 1 4 .482 ) ;2 0世纪 80年代初每月肉类摄入量 (OR =4.930 ,95%CI:2 .40 4～ 1 0 .1 1 1 ) ;舒张压 (OR =1 .0 50 ,95 %CI:1 .0 1 7～ 1 .0 83) ;吸烟量 (OR =0 .660 ,95 %CI:0 .50 0～ 0 .872 ) ;饮酒量 (OR =0 .650 ,95 %CI:0 .480～ 0 .881 )。结论 患前列腺炎、80年代初每月过多摄入肉类、舒张压高可能是BPH的危险因素 ;吸烟量大。

Objective To investigate the relation between various risk factors and benign prostatic hyperplasia (BPH). Methods A population based case control study was conducted, including 100 BPH patients over 60 years old living in suburb of Shenyang as study group, and 100 elderly men with non BPH (excluding prostatic cancer and prostatitis) as control group. χ 2 test and non conditional logistic regression were used for monovariate analysis and multivariate analysis, respectively. Results Data from monovariate analysis showed that BPH incidence was significantly related to body weight index, cigarette smoking, alcohol drinking, meal intake at the beginning of 1980's, hypertention and prostatitis, respectively. While multivariate non conditional logistic analysis showed that BPH was related to five factors: prostatitis ( OR = 5.577 , 95% CI : 2.147 14.482 ), monthly intake of meats at the beginning of 1980's ( OR = 4.930 ,95% CI : 2.404 10.111 ), diastolic blood pressure ( OR = 1.050 ,95% CI : 1.017 1.083 ), cigarette smoking ( OR = 0.660 ,95% CI : 0.500 0.872 ) and alcohol consumption ( OR = 0.650 ,95% CI : 0.480 0.881 ). Conclusion Prostatitis, monthly excessive intake of meats at the beginning of 1980's and high diastolic blood pressure were possible risk factors for BPH, while heavy cigarette smoking and alcohol consumption were possible protective factors for BPH.