淋球菌对抗生素耐药性的结果分析

The analysis of antibiotic resistance in Nesisseria gonorrhoeae

目的:了解淋球菌对5种抗生素的耐药情况。方法:对2000～2001年广西南宁地区分离的160株淋球菌,在系统鉴定的基础上,以琼脂稀释法测定了对青霉素、环丙沙星、头孢曲松、大观霉素和四环素的最小抑菌浓度(MIC),并根据世界卫生组织(WHO)标准判定其敏感、中度敏感及耐药性。结果:在检测的160株淋球菌菌株中,产青霉素酶淋球菌(PPNG)阳性率为4.4%,青霉素、环丙沙星、头孢曲松、大观霉素、四环素耐药率分别为78.1%、91.9%、3.1%、0.6%和48.1%。结论:南宁地区淋球菌耐药以环丙沙星为甚,青霉素和四环素次之,也出现了个别耐头孢曲松和耐大观霉素的淋球菌菌株。

Objective: To study the resistances of Neisseria gonorrhoeae to five antibiotics. Methods One hundred and sixty gonococcal isolates obtained for 2 years (2000-2001) in Nanning (Guangxi) were tested for their antibiotic susceptibilities based on the systemic identification. The minimum inhibitory concentrations (MIC) of penicillin ciprofloxacin ceftriaxone spectinomycin and tetracycline were tested according to WHO criteria. Results The result showed that the positive rates of PPNG were 4.4% in 160 gonococcal isolates. The percentage of the resistances to penicillin ciprofloxacin ceftriaxone spectinomycin and tetracycline were 78.1% 91.9% 3.1%0.6% and 48.1% respectively. Conclusions In Nanning the gonococci were highly resistant to ciprofloxacin next were to penicillin and tetracycline. And it was also found that a few of gonococcal isolates were resistant to ceftriaxone and spectinomycin.