急性脑梗死患者脑脊液肿瘤坏死因子、白细胞介素6和8的变化

Change of Tumor Necrosis Factor、Interleukin-6 and 8 in Cerebrospinal Fluid in Patients with Cerebral Infarction

为探讨脑梗死患者脑脊液中肿瘤坏死因子、白细胞介素 6、白细胞介素 8水平的动态变化 ,采用酶联免疫吸附法分别测定 3 0例脑梗死患者病期 <1周与病期 >4周以及 2 0例健康老年人的脑脊液中肿瘤坏死因子、白细胞介素 6、白细胞介素 8水平。结果发现 ,脑梗死患者脑脊液肿瘤坏死因子、白细胞介素 8水平较正常对照组增高 ,病期 <1周者脑脊液肿瘤坏死因子、白细胞介素 8水平较病期 >4周者显著升高 ;病期 >4周者肿瘤坏死因子、白细胞介素 8有明显下降 ,但仍高于正常对照组 ;病期 <1周者脑脊液白细胞介素 6水平与病期 >4周者相比无明显改变 (P >0 .0 5 ) ,但均高于正常对照组 ,而且神经功能缺损程度与脑脊液肿瘤坏死因子、白细胞介素 8的含量呈明显正相关关系。结果提示 ,脑脊液肿瘤坏死因子、白细胞介素 6、白细胞介素 8水平的动态监测对脑梗死发生。

Aim To study the change of tumor necrosis factor (TNF)? interleukin-6 (IL-6)? interleukin-8 (IL-8) in cerebrospinal fluid (CSF) in patients with cerebral infarction. Methods The level of TNF? IL-6? IL-8 in CSF in patients with cerebral infarction in the period<1 week and >4 week and in twenty heathy elderly persons as control were measured by ELISA respectively. Results The level of TNF? IL-6? IL-8 in CSF in patients with cerebral infarction was higher than normal control. The degree of raise about TNF? IL-8 in period<1 week was more significant than>4 week. The level of IL-6 had no relation with the stage of disease. And there was a positive correlation between the increasing degree of TNF? IL-8 and the degree of neurological deficits. Conclusion The measure of level of TNF? IL-8? IL-6 in CSF could be taken as index of prognosis of cerebral infarction.