血管内皮生长因子与冠状动脉粥样硬化及侧枝循环形成的关系

The Relationship between Vascular Endothelial Growth Factor and the Severity of Coronary Stenosis as well as Coronary Collateral Development

探讨血管内皮生长因子与冠状动脉粥样硬化狭窄程度及冠状动脉侧枝循环形成的关系 ,应用酶联免疫吸附法检测 10 2例经冠状动脉造影确诊的冠心病患者和 43例冠状动脉造影正常者的冠状动脉血浆血管内皮生长因子浓度 ,作冠状动脉病变Leaman记分和侧枝循环Rentrop分级 ,并分析血管内皮生长因子与其的关系。结果发现 ,冠心病患者冠状动脉血浆血管内皮生长因子平均浓度明显高于正常对照组 ( 2 2 5± 147ng L比 74± 5 2ng L ,P <0 .0 1) ,而且冠心病患者中侧枝循环形成者血管内皮生长因子平均浓度明显高于无侧枝循环形成者 ( 2 99± 15 2ng L比 2 0 2± 12 2ng L ,P <0 .0 5 ) ;血浆血管内皮生长因子浓度与Leaman记分呈显著正相关 (r=0 .693 ,P <0 .0 0 1)。结果提示 ,血管内皮生长因子与冠状动脉粥样硬化狭窄程度及冠状动脉侧枝循环形成具有一定的关系 ,血管内皮生长因子可能既有促进冠状动脉侧枝循环形成的作用 。

Aim To investigate the association between vascular endothelial growth factor (VEGF) and the severity of coronary lesions as well as coronary collateral development in patients with coronary heart disease. Methods The concentration of VEGF was measured by enzyme linked immunoserbent assay (ELISA) in 102 patients with angiographically documented coronary heart disease and 43 normal persons without any angiographically detectable coronary artery disease. The coronary artery score was recorded according to Leaman and the coronary collateral class was made according to Rentrop. The relationships between plasma VEGF and Leaman coronary artery score as well as coronary collateral circulation were assessed. Results The level of coronary artery plasma VEGF was obviously higher in the coronary disease group than in the control group (225±147 ng/L vs 74±52 ng/L ,P<0.01), and the mean VEGF was higher in coronary disease patients with collateral circulation than in patients without collateral circulation (299±152 ng/L vs 202±122 ng/L, P<0.01). The concentration of plasma VEGF was positively related to the Leaman score (r=0.693, P<0.001). Conclusions The plasma VEGF had correlation to both the severity of coronary stenosis and coronary collateral circulation in patients with coronary heart disease. VEGF might enhance collateral circulation development and doubly regulate the development of atherosclersis.