子宫内膜异位症患者腹腔液白介素6浓度的Meta分析

Meta-analysis of Interleukin-6 Concentration in Peritoneal Fluid of Women with Endometriosis

为了确定子宫内膜异位症 (EM )患者腹腔液白介素 6 (IL - 6 )浓度是否高于正常盆腔者 (对照组 ) ,本文采用Meta分析 ,对有关EM患者腹腔液IL - 6浓度报道的国内外文献资料进行定量综合分析。结果提示 :按ELISA法EM组腹腔液IL - 6的水平较对照组高出 (- 0 .4 72 - 3.974 )倍标准差。无论采取方法的不同 ,高出(- 0 .73- 3.4 5 )倍标准差 ,均提示不能笼统认为EM患者腹腔液IL - 6浓度较对照组高 ;但对按照美国生育协会 (AFS)校正标准将EM分期进行分组 :Ⅰ -Ⅱ期归为一组 (EMI组 ) ,Ⅲ -Ⅳ期归为一组 (EM 2组 )的资料 ,经Meta分析后 ,发现EM患者腹腔液IL - 6升高水平与EM的病情严重程度有较好的相关性 :其中EM 1组较对照组高出 (- 4 .80 7- 5 .6 0 8)倍标准差 ,两组间无差异 ;但EM 2组较EM 1组和对照组分别高出 (0 .5 4 - 5 .34) ,(1.13- 5 .4 6 )倍标准差 ,明显高于后两组。EM患者腹腔液IL - 6浓度随EM病变程度而升高 ,IL -

To investigate whether the Interleukin-6 (IL-6) concentration in peritoneal fluid of patients with endometriosis (EM) is higher than that of healthy, synthetic quantitative analysis was used to study international literatures on IL-6 in peritoneal fluid of women with EM by means of Meta-analysis. The results showed that IL-6 levels of ELISA in the women with EM were -0.472-3.974 times of standard deviation higher than those in the healthy control group. Regardless of measurement methods, -0.73-3.45 times of standard deviation was higher. Both results could not generally think that the IL-6 in peritoneal fluid of EM patient was higher than that of normal persons. However, when EM was diagnosed at the time of laparoscopy or surgery and staged according to AFS, Ⅰ-Ⅱ stage were attributed to EM1, Ⅲ-Ⅳ stage were EM2.It was found by Meta-analysis that the elevated IL-6 levels had a mutual relation with the severity of EM: The levels of EM1 were-4.807-5.608 times of standard deviation higher than those of then healthy, with no significant difference ( P >0.05), whereas those of EM2 were 0.54-5.34 times or 1.13 -5.46 times of standard deviation higher than those of EM1 or healthy, respectively, both with significant difference. The higher the IL-6 levels of the patients had in peritoneal fluid, the more serious EM were. The dysregulation of IL-6 responses might play a role in the pathophysiology of EM.