环境农药暴露和人群肺癌发病、死亡的相关分析

Correlation between environmental pesticides exposure and lung cancer morbidity and mortality in agricultural population

目的 研究环境中农药暴露与农业人群肺癌发病率和死亡率的相关关系。方法 利用生态比较研究方法 ,收集沈阳市郊区县农药接触人群 1993～ 1998年各年的农药使用种类、使用量和农作物播种种类、播种面积等资料 ,同时收集 1998～ 2 0 0 0年相应地区的肺癌发病和死亡资料。应用SPSS 10 0统计软件进行等级相关分析。结果 总的肺癌发病率与农药使用密度无显著性相关。年龄别分析表明 ,男性 4 0～ 4 9岁及女性 6 0～ 6 9岁年龄组的发病率与农药使用密度有显著性相关 ,P <0 0 5。 1998年男性及男、女合计的肺癌死亡率与 1993年农药使用密度有显著性相关 ,相关系数均为 0 886 ,P <0 0 5。按年龄别、性别分析显示 ,4 0～ 4 9岁年龄组的男性、女性和男、女合计的肺癌死亡率与农药使用密度有显著性相关 ,相关系数分别为 0 886 ,0 886 ,0 94 3。结论 农业人群肺癌的发病率和死亡率与环境中农药暴露存在一定的相关。

Objective To make sure whether there is significant correlation between environmental pesticides exposure and lung cancer morbidity or mortality in agricultural population.Methods Ecological comparing method is used to collect both 1993-1998 pesticides using data and 1998-2000 lung cancer morbidity and mortality data in Shenyang subdurban area.The coefficients of spearsman correlation between pesticides exposure and lung cancer morbidity or mortality are calculated by SPSS 10.0 statistical software.Results The correlation between pesticides using density and morbidity of lung cancer is not significant,except 40-49 in male and 60-69 in female( P <0 05).Mortality of 1998 in both male and all sex is significant positive correlation with pesticides use density of 1993.The coefficients of correlation are equal to 0.886( P <0 05).Sex,age-specific analysis show that mortality of 40-49 in male,female and all sex are positive significant correlation with pesticides using density.The coefficients of correlation are 0.886,0.886 and 0.943,respectively.Conclusion There is correlation between environmental pesticides exposure and lung cancer morbidity or mortality to some extent.