丁苯酞对重度老年OSAHS患者血浆一氧化氮和内皮素-1的影响

Effects of butylphthalide on plasma nitric oxide and endothelin-1 in severe elderly OSAHS patients

目的:探讨丁苯酞对重度老年OSAHS患者血浆一氧化氮(NO)和内皮素-1(ET-1)的影响及临床意义。方法:将120例经PSG确诊的重度老年OSAHS患者随机分为无创呼吸机对照组、丁苯酞治疗组和丁苯酞联合无创呼吸机组,每组40例。无创呼吸机对照组患者行双水平气道正压通气治疗6个月,丁苯酞治疗组患者口服丁苯酞治疗6个月,丁苯酞联合无创呼吸机组患者在行双水平气道正压通气治疗的同时,口服丁苯酞治疗6个月,分别于治疗前及治疗3、6个月后采用免疫酶联吸附法检测血浆NO、ET-1水平的变化,并进行对比分析。结果:3组患者治疗前血浆NO和ET-1比较差异无统计学意义(P>0.05);与治疗前比较,3组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降(P<0.01);与丁苯酞治疗组治疗后比较,无创呼吸机对照组及丁苯酞联合无创呼吸机组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降,差异有统计学意义(P<0.05);与无创呼吸机对照组比较,丁苯酞联合无创呼吸机组患者治疗3、6个月后血浆NO水平升高,ET-1水平下降,差异有统计学意义(P<0.05)。结论:丁苯酞可通过升高血浆NO、降低血浆ET-1的水平改善重度老年OSAHS患者的血管内皮功能。

Objective:To investigate the effect of butylphthalide on plasma nitric oxide(NO)and endothelin-1(ET-1)in severe elderly OSAHS patients.Method:A total of 120 severe elderly OSAHS patients were chosen by PSG measurement.According to random number table method,OSAHS patients were randomly divided into noninvasive ventilation control group(n=40),butylphthalide treatment group(n=40)and butylphthalide combined with non-invasive ventilation group(n=40).Non-invasive ventilation control group was given double level airway positive pressure ventilation treatment for six months,butylphthalide treatment group accepted oral butylphthalide therapy for six months,butylphthalide combined with non-invasive ventilation group was given double level airway positive pressure ventilation treatment and accepted oral butylphthalide therapy for six months.The changes of plasma NO and ET-1 were detected by immunoenzyme adsorption before treatment and three and six months after treatment.Result:The difference of plasma NO and ET-1 before treatment in the three groups was not statistically significant(P>0.05).Compared with before treatment,the level of plasma NO decreased and the level of plasma ET-1 increased in the three groups after three and six months treatment(P <0.01).Compared with butylphthalide treatment group,the level of plasma NO increased and the level of plasma ET-1 decreased after 3 and 6 months of treatment in both non-invasive ventilation control group and butylphthalide combined with non-invasive ventilation group(P<0.05).Compared with non-invasive ventilation control group,the level of plasma NO increased and the level of plasma ET-1 decreased after 3 and 6 months of treatment in butylphthalide combined with non-invasive ventilation group(P<0.05).Conclusion:Butylphthalide may improve the vascular endothelial function of severe elderly OSAHS patients by increasing the level of NO and decreasing the level of ET-1 in plasma.