长链非编码RNA LINC00152在喉鳞状细胞癌中的表达及其临床意义

Expression of long-chain non-coding RNA LINC00152 in laryngeal squamous cell carcinoma and its clinical significance

目的:探讨长链非编码RNA LINC00152在喉鳞状细胞癌(LSCC)中的表达及其与临床病理特征的相关性。方法:通过实时荧光定量PCR的方法,检测LINC00152在LSCC细胞系以及36对LSCC癌组织与配对癌旁正常组织中的相对表达水平,并分析其表达水平与患者年龄、吸烟、饮酒、病理分化程度、临床分期及颈部淋巴结转移的相关性。结果:LINC00152在LSCC细胞系中呈高表达,且在癌组织中的相对表达水平明显高于配对癌旁正常组织(P=0.006),其表达水平与患者病理分化程度(P=0.032)、临床分期(P=0.044)相关,与患者年龄、吸烟、饮酒及颈部淋巴结转移无明显相关性(P>0.05)。结论:LINC00152在LSCC中表达增高,其有可能作为LSCC临床诊断、治疗和预后的标志物。

Objective:The aim of this study is to explore the relative expression level of LINC00152 in laryngeal squamous cell carcinoma(LSCC)and its clinical significance.Method:The relative expression levels of LINC00152 in LSCC cell lines and 36 paired LSCC specimens were measured by qRT-PCR method.And the correlations between the expression level of LINC00152 and the clinical features derived from LSCC patients were analyzed and compared through the independent sample t-test.Result:The relative expression level of LINC00152 was over-expressed in LSCC cell lines and cancerous tissues than that in paired adjacent normal tissues,and the difference was statistically significant(P=0.006).Even the associations between LINC00152 expression level and clinicopathological features(P=0.044 for clinical stage,P=0.032 for pathological differentiation degree)were significantly.Conclusion:LINC00152 is highly expressed in LSCC and it may become a new tumor marker for the diagnosis and prognosis of LSCC.