红景天对OSA患者氧化应激及负性情绪状况的影响

Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea

目的:探讨红景天对OSA患者氧化应激及焦虑、抑郁负性情绪的影响。方法:选90例经PSG、自评抑郁量表(SDS)及焦虑自评量表(SAS)评分确诊的中重度OSA合并负性情绪的患者,根据随机数字表法随机分为无创呼吸机组、红景天+无创呼吸机组及红景天组,每组30例,无创呼吸机组患者采取持续气道正压通气(CPAP)治疗3个月,红景天+无创呼吸机组在CPAP基础上给予口服红景天胶囊治疗3个月,红景天治疗组采用单纯口服红景天胶囊治疗3个月。比较3组治疗前后SDS和SAS评分的变化,同时采用免疫酶联吸附法检测SOD和MDA的变化,并进行对比分析。结果:3组患者治疗前SDS、SAS得分相比,差异无统计学意义(P>0.05);与治疗前比较,3组患者治疗后SDS、SAS评分均下降(P<0.05)。与无创呼吸机组治疗后比较,红景天+无创呼吸机组患者治疗后SDS、SAS评分均下降(P<0.05),红景天组患者治疗后SDS、SAS评分均升高(P<0.05),与红景天治疗组治疗后比较,红景天+无创呼吸机组患者治疗后SDS、SAS评分均下降(P<0.05);3组患者治疗前血清超氧化物歧化酶(SOD)和丙二醛(MDA)相比差异无统计学意义(P>0.05);与治疗前比较,3组患者治疗后血清SOD水平均升高,MDA水平均下降(P<0.05)。与无创呼吸机组治疗后比较,红景天+无创呼吸机组患者治疗后血清SOD水平升高,MDA水平下降(P<0.05),而红景天治疗组患者治疗后血清SOD水平下降,MDA水平升高(P<0.05),与红景天治疗组治疗后比较,红景天+无创呼吸机组患者治疗后血清SOD水平升高,MDA水平下降(P<0.05);结论:红景天可能通过抑制OSA患者机体氧自由基和脂质过氧化,进而改善患者焦虑、抑郁等负性情绪。

Objective:The aim of this study is to investigate the effects of rhodiola rosea on oxidative stress,anxiety and depression in patients with OSA.Method:Ninety patients with moderate and severe OSA patients with negative emotions diagnosed by PSG,self-rating depression scale(SDS)and self-rating anxiety scale(SAS)were selected from the respiratory department of our hospital from February 2015 to February 2018.According to the random number table method,the patients were randomly divided into non-invasive ventilator group,rhodiola rosea+non-invasive ventilator group and rhodiola rosea group,with 30 cases in each group.Patients in the non-invasive ventilator group were treated with continuous positive airway pressure(CPAP)for 3 months,and those in the rhodiola rosea+non-invasive ventilator group were treated with oral rhodiola capsules for 3 months on the basis of CPAP,and those in the rhodiola rosea treatment group were treated with pure oral rhodiola capsules for 3 months.The changes of SDS and SAS before and after the three groups were compared,and the changes of serum SOD and MDA were detected by immunoenzyme-linked adsorption for comparative analysis.Result:There were no significant differences in SDS and SAS scores between the three groups(P>0.05).SDS and SAS scores of patients in the rhodiola rosea+non-invasive ventilator group decreased after treatment(P<0.05)compared with those in the non-invasive ventilator group.SDS and SAS scores of patients in the rhodiola treatment group increased after treatment(P<0.05).Compared with those in the rhodiola treatment group,SDS and SAS scores of patients in the rhodiola+non-invasive breathing group decreased after treatment(P<0.05).Three group patients were no significant difference in serum SOD and malondialdehyde(MDA)before treatment(P>0.05).Compared with before treatment,serum SOD level were all increased and MDA level were all decreased in the three groups after treatment(P<0.05).Compared with noninvasive breathing unit after treatment,rhodiola+noninvasive breathing unit after treatment in patients with elevated levels of serum SOD,MDA level decreased(P<0.05),and for the treatment group after treatment in patients with serum SOD levels drop,the MDA levels(P<0.05),and the after rhodiola rosea treatment group compared,rhodiola+noninvasive breathing unit after treatment in patients with elevated levels of serum SOD,MDA level decreased(P<0.05).Conclusion:Rhodiola may improve the negative emotions such as anxiety and depression by inhibiting oxygen free radicals and lipid peroxidation in patients with OSA.