IDEAL-IQ对非酒精性脂肪肝患者胰腺脂肪含量的定量评估

Evaluation of Pancreatic Fat Quantification in Patients with Non-Alcoholic Fatty Liver Disease( NAFLD) by using IDEAL-IQ

目的探讨应用IDEAL-IQ评估非酒精性脂肪肝患者胰腺脂肪含量的价值。方法搜集于大连医科大学附属第一医院行上腹部1.5 T MRI检查并患有非酒精性脂肪肝的患者21例(A组);同时搜集同期与其年龄和体质量指数(BMI)相匹配的正常对照者24名(B组)。应用IDEAL Research软件进行图像自动重组,获得脂肪分数、弛豫率(R_2~*)、水相、脂相共4幅图像。将脂肪分数图像传至AW 4.6工作站,经Compare软件进行测量。由两名观察者(诊断经验分别为3年和5年)采用双盲法对脂肪分数图进行测量。采用SPSS 19.0软件对数据进行统计学分析。结果两名观察者所测得的数据一致性良好。两组间年龄、BMI以及性别差异无统计学意义。两组间胰腺各部位以及全胰腺平均脂肪含量的差异具有统计学意义(P<0.05)。A组内胰腺钩突部、头颈部、体部、尾部以及全胰腺平均脂肪分数值分别为7.55(6.00～11.48)、8.10(6.37～8.92)、7.44±2.98、7.92(6.17～8.53)、7.94±4.31,差异无统计学意义(P>0.05),B组内胰腺钩突部、头颈部、体部、尾部以及全胰腺平均脂肪分数值分别为5.16(4.66～5.88)、5.03(4.75～5.67)、4.76±0.20、 4.81(4.53～5.34)、5.07±0.39,差异具有统计学意义(P<0.05)。结论 IDEAL-IQ是用于评估非酒精性脂肪肝患者的胰腺脂肪定量的新颖、便捷的方法。非酒精性脂肪肝患者的胰腺脂肪含量明显高于正常人,并且非酒精性脂肪肝患者胰腺脂肪在胰腺各部位的分布是均匀的,而平均年龄约56岁的正常人胰腺脂肪在胰腺各部位的分布是不均匀的,其胰腺头部和钩突部的脂肪含量更多。

Objective To detect the correlation between NAFLD and pancreatic fat quantification by use of IDEAL-IQ.Methods Twenty-one inpatients with NAFLD,that underwent upper abdomen MRI at 1.5 T(GE 1.5 T Signa HDXT,America),which included IDEAL-IQ,were included(group A).At the same time,twenty-four normal subjects matched with age and BMI were collected(group B).The images were reconstructed automatically by IDEAL research software,and fat fraction,R2*,water phase and lipid phase were obtained.The fat fraction image was sent to the AW4.6 workstation and measured by compare software.The images were analyzed and measured by two radiologists with double blind method.The data were analyzed by using SPSS 19.0.Results The data measured by the two observers were in good agreement.The difference in age,BMI,and gender between the two groups was not statistically significant(P>0.05).The fat fraction(%)of uncinate process,head and neck,body and tail of the pancreas of group A and group B were 7.55(6.00-11.48),8.10(6.37-8.92),7.44±2.98,7.92(6.17-8.53),7.94±4.31;5.16(4.66-5.88),5.03(4.75-5.67),4.76±0.20,4.81(4.53-5.34),5.07±0.39,respectively,the difference between the two groups in different parts of the pancreas and pancreatic average fat fraction were statistically significant(P<0.05).There weren’t significant differences in the fat fraction in each region of pancreas in group A(P>0.05),but there were significant differences in the fat fraction in each region of pancreas in group B(P<0.05).Conclusion IDEAL-IQ is a new way to evaluate the pancreatic fat quantification in patients with NAFLD.The fat fraction of the pancreas in patients with NAFLD is significantly higher than that in normal subjects,and the distribution of pancreatic fat in various regions of the pancreas in the NAFLD patients is well,but it is uneven in the normal subjects with an average age 56 years old,and the fat in uncinate process and head and neck is more than that in the body and tail of the pancreas.