阻塞性睡眠呼吸暂停患者前、后默认网络功能连接分离的研究

Separation of Functional Connections on the Anterior and Posterior Default Network in Patients with Obstructive Sleep Apnea

目的研究阻塞性睡眠呼吸暂停(OSA)患者前、后默认网络功能连接情况,探讨OSA患者认知功能损害的潜在神经生理机制。方法采集43例OSA患者(OSA组)及43名健康男性(HC组)的静息态磁共振脑功能成像(rs-fMRI)和临床量表评估数据。选用基于种子点的功能连接方法,分别以内侧前额叶(mPFC)和后扣带回(PCC)为种子点计算其与全脑的功能连接值,组间的功能连接差异比较采用双样本t检验。结果与HC组相比,OSA组mPFC与左侧小脑后叶功能连接减低,而与左侧顶下小叶、双侧额中回、左侧额下回功能连接增高;OSA组PCC与双侧中央后回、右侧中央前回功能连接减低,而与右侧小脑后叶功能连接增高。结论 OSA患者前、后默认网络功能连接存在显著差异,这可能为进一步理解OSA认知功能的损害提供了新的视角。

Objective To investigate the functional connections of the anterior and posterior default network and to explore the potential neurophysiological mechanism of cognitive impairment in patients with OSA.Methods Collected the resting-state magnetic resonance functional imaging(rs-fMRI)data of 43 OSA patients and 43 healthy control(HC).We used seed-based method,selected the seeds in the Medial prefrontal lobe(mPFC)and posterior cingulate gyrus(PCC)respectivly,to calculate the functional connection with the whole-brain.And we compared the functional connectivity differences between groups by using two sample t-test.Results Compared to the HCs,in patient with OSA,the functional connections with mPFC were decreased dramatically in the left posterior cerebellar lobe while they increased significantly in the left inferior parietal lobule,bilateral middle frontal gyrus and left inferior frontal gyrus.For the PCC seed,bilateral postcentral gyrus and right precentral gyrus showed significant decrease,and only the right posterior cerebellum showed significant increase in patient with OSA.Conclusion The anterior and posterior default network in the patient with OSA shows great differences,and it may provide a new perspective for further investigate the reduction of cognitive function in patients of OSA.