自体骨髓干细胞治疗肝硬化的应用及管理

Application and management of autologous bone marrow stem cells in treatment of liver cirrhosis

肝移植被认为是治疗肝硬化的最佳方式,但因供体不足、费用较高、免疫排斥等原因而受到限制。近年来骨髓干细胞在治疗肝硬化上展示出了广阔前景。目前已有大量临床试验表明自体骨髓干细胞治疗肝硬化是一种安全、有效的治疗方式,但其机制并不清楚,且治疗方案有多种选择。就骨髓干细胞治疗肝硬化的机制、骨髓干细胞输入通路、疗效评估指标、细胞输入剂量等进行综述。

Liver transplantation is considered the best method for the treatment of liver cirrhosis,but its clinical application is limited by the shortage of liver donors,high costs,and immunological rejection.In recent years,bone marrow stem cells(BMSCs)has shown great prospects in the treatment of liver cirrhosis.Recent clinical studies have shown that BMSC therapy is a safe and effective treatment method for liver cirrhosis,but its mechanism remains unclear,and there are various treatment regimens.This article reviews the mechanism of BMSCs in the treatment of liver cirrhosis,route of BMSC delivery,indices for therapeutic effect evaluation,and dose of BMSCs.