原发性肝癌的营养代谢特点及意义

Features and clinical significance of nutritional metabolism in patients with primary liver cancer

营养代谢与肿瘤的治疗密切相关,一方面,以营养代谢通路分子作为治疗靶点,成为生物医学领域研究的新方向;另一方面,肿瘤患者营养状态较差,将导致患者无法进行治疗、副作用较大或预后较差。肝肿瘤代谢具有区别于其他部位肿瘤的营养代谢特点,因此,肝癌患者的营养代谢研究尤为重要。对原发性肝癌患者糖、脂肪、蛋白质和氨基酸代谢的变化及分子机制进行阐述,以期为肝癌患者营养代谢通路的选择、肝癌特异性标志物的确定以及治疗中的营养支持等问题提供解决思路,为肝癌的营养代谢研究提供参考。

Nutritional metabolism is closely associated with the treatment of tumors and is an important research field in China and foreign countries.On the one hand,the use of nutrient metabolism pathway molecules as therapeutic targets has become a new direction in the field of biomedical research;on the other hand,poor nutritional status in patients with tumors will lead to the fact that the patients cannot be treated or have severe adverse reactions or poor prognosis,and thus it has always been a hot research topic.The liver is a metabolic organ,and the metabolism of liver tumors is different from that of tumors in other parts.Therefore,the research on nutritional metabolism in patients with liver cancer is of particular importance.This article elaborates on the changes in the metabolism of glucose,lipids,proteins,and amino acids and related molecular mechanisms in patients with primary liver cancer,in order to provide thoughts for selecting nutrient metabolism pathways in patients with liver cancer,identifying specific markers for liver cancer,and solving the issue of nutritional support during treatment and provide a reference for the research on nutritional metabolism of liver cancer.