核因子E2相关因子2抗氧化通路与肝脏疾病的关系

Association between nuclear factor-erythroid 2-related factor-2 antioxidant pathway and liver diseases

核因子E2相关因子2(Nrf2)是细胞抵御氧化应激的一个重要转录因子,其与抗氧化反应元件相互作用,从而诱导下游保护性II相解毒酶和抗氧化酶的表达,起到细胞的保护作用。氧化应激是众多肝脏疾病共同的发病机制,而Nrf2-抗氧化反应元件是体内重要的抗氧化应激通路,该通路通过诱导下游靶基因的表达,在肝脏疾病的发生、发展及预防过程中起重要作用。简述了Nrf2抗氧化通路在肝脏疾病发生发展过程中的作用机制。认为Nrf2可能成为预防或治疗肝脏疾病的一个潜在靶点。

Nuclear factor-erythroid 2-related factor-2(Nrf2)is an important transcription factor for cells to resist oxidative stress.It interacts with antioxidant response elements to induce the expression of downstream protective phase II detoxification enzymes and antioxidant enzymes and thus exerts a protective effect on cells.Oxidative stress is the common pathogenesis of many liver diseases,and the Nrf2-ARE antioxidant pathway is an important anti-oxidative stress pathway in vivo.It can induce the expression of downstream target genes and thus plays an important role in the development,progression,and prevention of liver diseases.This article briefly describes the mechanism of action of the Nrf2 antioxidant pathway in the development and progression of liver diseases and points out that Nrf2 may be a potential target for the prevention or treatment of liver diseases.