钛表面微波水热联合药物涂覆的体外活性研究

In vitro activity of microwave hydrothermal composite drug coating on titanium surface

目的:研究钛铌锆锡合金(Ti-24Nb-4Zr-8Sn,Ti2448)微弧氧化涂层表面微波水热复合药物涂层的微观结构变化及其在模拟体液中磷灰石形成的能力。方法:商业化的Ti2448试件30个,每组10个试件,随机分为3组,对照组(MAO组)经Ti2448表面微弧氧化处理,实验组1(MH组)经MAO处理后再进行微波水热处理,实验组2(DC组)经MH处理后进行药物涂覆处理。采用扫描电子显微镜(SEM)和X射线衍射仪(XRD)对试样表面组织结构及磷灰石诱导能力进行观察分析。结果:SEM观察MAO组呈现多孔粗糙的表面,MH组表面形成磷灰石纳米棒的同时保留多孔粗糙的结构,DC组表面被部分药物涂层覆盖,纳米棒和多孔结构部分消失。经过模拟体液浸泡后,XRD显示MH组和DC组表面有磷灰石形成。结论:微波水热复合药物涂覆后钛种植体具有良好的体外磷灰石诱导能力。

Objective:To study the microstructure changes of microwave hydrothermal combined with drug coating on microarc oxidation coating on Ti-24Nb-4Zr-8Sn alloy(Ti2448)and the ability of simulating apatite in body fluid.Methods:The experiment was divided into three groups that control group(MAO group)with Ti2448 surface microarc oxidation treatment,experimental group 1(MH group)with microwave hydrothermal treatment after MAO treatment,and experimental group 2(DC group)with drug coating treatment after MH treatment.The surface structure and apatite inducing ability of the samples were observed and analyzed by scanning electron microscop(SEM)and X-ray diffraction(XRD).Results:SEM showed that the microarc oxidation coating exhibited a porous rough surface,the apatite nanorods having a certain orientation were formed on the MH surface,while retaining the porous and rough structure,and the DC surface was covered with a part of the drug coating,and the nanorods and the porous structure partially disappeared.After the simulated body fluid immersion,XRD showed apatite formation on the surface of MH and DC groups.Conclusion:Titanium implants have good in vitro apatite induction ability after microwave hydrothermal combined with drug coating.