右美托咪定对前列腺癌患者术后认知功能及血清神经功能指标的影响

Effects of dexmedetomidine on postoperative cognitive function and serum neurologic indexes in patients with prostate cancer

目的:研究右美托咪定对前列腺癌患者术后认知功能及血清神经功能指标的影响。方法:选取2016年4月～2018年3月我院收治的80例行腹腔镜前列腺癌根治术患者,根据是否应用右美托咪定随机分为右美托咪定组和对照组,每组40例。比较两组患者术前1 d、术后1 d、术后3 d的简易精神状态量表(MMSE)评分及血清神经功能指标情况。结果:两组患者术后1、3 d的MMSE评分均低于术前,右美托咪定组术后1、3 d的MMSE评分显著高于对照组(P<0.05)。两组患者术后1、3 d的人神经特异性烯醇化酶(NSE)水平较术前显著升高(P<0.05),人胰岛素样生长因子1(IGF-1)、转化生长因子β1(TGF-β1)较术前显著降低,其中右美托咪定组NSE升高幅度显著小于对照组(P<0.05),IGF-1、TGF-β1降低幅度显著小于对照组(P<0.05)。结论:在前列腺癌患者术中应用右美托咪定能有效改善患者认知功能,对患者的脑组织有很好的保护作用。

Objective:To study the effect of dexmedetomidine on postoperative cognitive function and serum neurologic indexes in patients with prostate cancer.Method:Selected 80 patients who received laparoscopic radical prostatectomy from April 2016 to March 2018,were randomly divided into the dexmedetomidine group and the control group with 40 cases in each group.The MMSE score and serum nerve function index of the two groups on 1 day before surgery,1 day after surgery and 3 days after surgery were compared.Result:The MMSE score 1 day and 3 days after surgery were lower than those before surgery in both groups,and the MMSE score of the dexmedetomidine group was significantly higher than that of the control group(P<0.05).One day and 3 days after surgery,the level of NSE in the two groups were significantly higher(P<0.05),but IGF-1 and TGF-β1 were significantly lower.The increase of NSE in the dexmedetomidine group was significantly lower than that in the control group(P<0.05),and the decrease of IGF-1 and TGF-β1 were significantly lower than those in the control group(P<0.05).Conclusion:The application of dexmedetomidine can effectively improve the cognitive function and protect the brain of patients with prostate cancer.