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肝癌干细胞耐药机制及靶向治疗研究进展

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摘要 肝癌是我国常见的恶性肿瘤之一,早期病情隐匿难以发现,做出诊断时大多已经晚期不能手术切除,并且表现出较强的放化疗抵抗特性。目前研究发现肿瘤中存在一部分细胞,具有干细胞样表型,被称之为肿瘤起始细胞或肿瘤干细胞。肿瘤干细胞具有自我更新和分化的能力,据认为是肿瘤发生、复发的根源。肿瘤干细胞可以通过多种机制产生化疗耐药,常规化疗药物仅可以杀死快速增殖的普通细胞,对肿瘤干细胞作用很差。明确肝癌干细胞耐药机制有助于寻找有效靶向肝癌干细胞的治疗策略,从而提高肝癌的临床治疗效果。
出处 《临床普外科电子杂志》 2014年第2期1-7,共7页 Journal of General Surgery for Clinicians(Electronic Version)
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