慢性肾脏病与心血管疾病关系的研究进展

Research progress in chronic kidney diseases and cardiovascular diseases

心脏和肾脏作为控制机体有效循环和血流动力学的两个重要器官,在生理功能上互相依存、在病理状态下互相影响,在治疗上又有很多共同之处。慢性肾脏病(CKD)是一种严重危害人类健康和生命的常见疾病。CKD不仅是终末期肾病(ESRD)的高危因素,也是心血管和全因死亡的高危因素,因此防治目标不仅要减缓、控制肾功能的进行性恶化,而且要预防主要的致死性合并症——心血管疾病(cardiovascular disease,CVD)的发生及恶化。但CKD患者CVD的发病机制、危险因素及治疗预防都是非常棘手和复杂的,故本文就CKD患者CVD的发病机制、危险因素、治疗及预防等三个方面作一综述。

As two important organs controlling the effective circulation and hemodynamics of the body, heart and kidney are interdependent in physiological function and influence each other in pathological state, and have much in common in treatment. Chronic kidney disease(CKD) is a common disease that seriously endangers human health and life. CKD is not only a high risk factor of end stage renal disease(ESRD), but also a high risk factor of cardiovascular and all-cause death. Therefore, the prevention and treatment objectives should not only slow down and control the progressive deterioration of renal function, but also prevent the occurrence and deterioration of cardiovascular disease(CVD), the main fatal complication. However, the pathogenesis, risk factors and treatment and prevention of CVD in CKD patients are very difficult and complex. This article reviews the pathogenesis, risk factors, treatment and prevention of CVD in CKD patients.