轻度认知功能障碍患者情绪记忆损害特征

Characteristics of emotional memory impairment in patients with mild cognitive impairment

目的探讨轻度认知功能障碍(MCI)患者情绪记忆的改变。方法采用情绪记忆神经认知心理学检查评价22例MCI患者(MCI组)及22名健康成年人(正常对照组)的情绪记忆,并采用事件诱发电位(ERPs)检测P300的潜伏期和波幅。结果与正常对照组比较,MCI组MMSE、词汇流畅性试验、数字广度试验评分均显著降低(均P <0. 01)。MCI组与正常对照组正性、中性和负性情绪图片效价度差异无统计学意义(均P> 0. 05)。与正常对照组比较,MCI组正性和负性图片再认正确率均显著降低(P <0. 05～0. 01),中性图片再认正确率差异无统计学意义(P> 0. 05)。MCI组及正常对照组正性、负性与中性图片再认正确率差异有统计学意义(F=6. 27,F=39. 13;均P <0. 05)。与正常对照组比较,MCI组正性和负性图片再认反应时间差异有统计学意义(P <0. 05～0. 01),中性图片差异无统计学意义(P> 0. 05)。MCI组及正常对照组正性、负性与中性图片再认反应时间差异有统计学意义(F=3. 74,F=16. 48;均P <0. 05)。MCI组与正常对照组学习阶段ERPs-P300的潜伏期、波幅差异无统计学意义(均P> 0. 05)。与正常对照组比较,MCI组再认阶段正性和负性图片ERPs-P300潜伏期显著增加,波幅显著降低(P <0. 05～0. 01);中性图片潜伏期及波幅差异无统计学意义(均P> 0. 05)。MCI组学习阶段(F=55. 20,P <0. 05; F=43. 12,P <0. 05)及再认阶段(F=29. 36,P <0. 05; F=19. 39,P <0. 05)正性、负性与中性情绪图片ERPs-P300潜伏期及波幅差异均有统计学意义;正性与负性ERPs-P300潜伏期及波幅比较差异无统计学意义(均P> 0. 05)。正常对照组的学习阶段(F=55. 66,P <0. 05; F=39. 33,P <0. 05)及再认阶段(F=114. 48,P <0. 05; F=51. 77,P <0. 05)正性、负性与中性情绪图片ERPs-P300潜伏期及波幅差异均有统计学意义。结论 MCI患者存在情绪记忆的受损及反应时间延长,且情绪效价"正向"选择性偏向受损。

Objective To explore the change of emotional memory in patients with mild cognitive impairment(MCI).Methods The emotional memory in 22 MCI patients(MCI group)and 22 healthy controls(normal control group)was evaluated by emotional memory neuro-cognitive test.The event-related evoked potentials(ERPs)-P300 latency and amplitude were detected by ERPs test.Results Compared with those in normal control group,MMSE,verbal fluency test and digital span test scores of MCI group were significantly lower(all P<0.01).There was no significant difference in the scores of positive,neutral and negative emotion picture valence between MCI group and normal control group(all P>0.05).Compared with those in normal control group,the correct rate of positive and negative valence pictures in MCI group were significantly lower(P<0.05-0.01),and there was no significant difference in the correct rate of neutral valence pictures recognition(P>0.05).There was significant difference in the correct rate of positive,negative and neutral valence pictures between MCI group and normal control group(F=6.27,F=39.13;all P<0.05).Compared with that in normal control group,there was significant difference in recognition reaction time between positive and negative valence pictures in MCI group(P<0.05-0.01),and there was no significant difference in neutral valence pictures(P>0.05).There was significant difference in recognition reaction time between positive,negative and neutral valence pictures in MCI group and control group(F=3.74,F=16.48;all P<0.05).There were no significant differences in the latency and amplitude of ERPs-P300 between MCI group and control group(all P>0.05).Compared with those in normal control group,the positive and negative valence pictures of MCI group showed the latency of ERPs-P300 was significant increase,and the amplitude was significantly decreased in recognition stage(P<0.05-0.01);there was no significant difference in the latency and amplitude of neutral valence pictures(all P>0.05).ERPs-P300 latency and amplitude of positive,negative and neutral valence pictures in learning stage(F=55.20,P<0.05;F=43.12,P<0.05)and recognition stage(F=29.36,P<0.05;F=19.39,P<0.05)in MCI group had significant difference,and ERPs-P300 latency and amplitude of positive and negative valence pictures in MCI group had no significant difference(all P>0.05).ERPs-P300 latency and amplitude of positive,negative and neutral negative valence pictures in learning stage(F=55.66,P<0.05;F=39.33,P<0.05)and recognition stage(F=114.48,P<0.05;F=51.77,P<0.05)in normal control group had significant difference.Conclusions Emotional memory of MCI patients is impaired,and recognition reaction time is prolonged.The selective bias of emotional valence is impaired.