IL-1β在急性胰腺炎时肝损伤中的作用

The role of IL-1β in the acute pancreatitis with hepatic function damage

目的观察白细胞介素(IL)-1β水平的变化,在急性胰腺炎时肝损伤发生、发展中的作用。方法 2015年9月~2017年9月在我科住院治疗的非胆源性急性胰腺炎合并肝损伤病人60例,根据腹部CT结果将病人分为两组,轻型急性胰腺炎组(MAP)30例,重型胰腺炎组(SAP)30例,对照组30例,为同时段体检中心体检的健康成人。采用全自动生化仪检测丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)指标,采用双抗体夹心ELISA法检测各组病人IL-1β水平。结果与对照组比较,MAP组及SAP组ALT、AST、及IL-1β水平均高于对照组(P<0.05),其中SAP组ALT、AST、及IL-1β水平高于MAP组,差异有统计学意义(P<0.05)。结论 IL-1β可能参与了急性胰腺炎肝功能损伤的发生,IL-1β水平与肝损伤的严重程度呈正相关。

Objective To explore the content change of IL-1βand to investigate the role of IL-1βon the hepatic function damage of acute pancreatitis.Methods Sixty patients of non-biliary acute pancreatitis with hepatic function damage from Sept 2015 to Sept 2017,according to CT grading divided into mild acute pancreatitis(MAP)with 30 cases and severe acute pancreatitis(SAP)with 30 cases,selected 30 cases of healthy people as the control group.By using automatic bichemical analyzer to test the level of ALT and AST,using radioimmunoassay to test the level of IL-1β,then statistical analysis was conducted.Results The level of ALT、AST and IL-1βin MAP and SAP group were higher than in the control group(P<0.05),the level of ALT、AST and IL-1βin SAP group were higher than in the MAP group,all had statistical significance(P<0.05).Conclusion IL-1βmay be involved in the process of hepatic function damage with acute pancreatitis,and the level of IL-1βis positively correlated with the severity of hepatic function damage.