IgA型多发性骨髓瘤患者预后因素分析

Analysis of prognostic factors in patients with IgA type multiple myeloma

目的:探究初诊IgA型多发性骨髓瘤(MM)患者临床相关指标和临床分期与预后关系,以期提高对该型MM的认识。方法:收集43例初诊为IgA型MM患者的临床资料,分析初诊时各临床指标与无进展生存时间(PFS)、总生存时间(OS)的关系。结果:单因素分析结果显示,对PFS有显著影响的是年龄>60岁,白蛋白≤30g/L,化疗方案(非硼替佐米组),缓解情况(疾病稳定+疾病进展);对OS有显著影响的是年龄>60岁,白蛋白≤30g/L,缓解情况(疾病稳定+疾病进展)。多因素分析结果显示,白蛋白≤30g/L是影响患者PFS的独立预后不良因素;年龄>60岁、白蛋白≤30g/L是影响患者OS的独立预后不良因素。结论:IgA型MM的预后与血清白蛋白、年龄有关,可以用来评估此类型患者的总体生存时间。

Objective:To explore the correlation between the prognosis of patients newly diagnosed with IgA type multiple myeloma(MM)and the level of their clinical staging and related indicators,so that we can improve the understanding of this type of MM.Method:The clinical data of 43 cases of IgA type MM initially diagnosed were collected.The relationship between the clinical indicators and the time of progression-free survival(PFS)and total survival(OS)was analyzed.Result:Univariate analysis showed that age>60 years old,albumin ≤30 g/L,chemotherapy regimen(non-borotezomib group)and remission(SD+PD)had significant effect on PFS.Significant effect on OS was seen in age>60 years old,albumin≤30 g/L and remission(SD+PD).Multi-factor analysis showed that albumin≤30 g/L was an independent prognostic factor influencing PFS of patients.Age>60 years old and albumin ≤30 g/L were the independent prognostic factors influencing OS of patients.Conclusion:The prognosis of IgA type MM is related to serum albumin and age,which can be used to evaluate the overall survival time of this type of patients.