伏立康唑口服给药的临床应用探讨

Exploring clinical application of oral voriconazole

伏立康唑(Voriconazole)具有抗菌谱广、疗效强的特点,是曲霉菌(Aspergillus)感染治疗的首选用药,对念珠菌(Candida)、隐球菌(Cryptococcus)、镰刀菌(Fusarium)等真菌感染亦有较好的效果[1-5]。具有针剂与口服制剂两种剂型,其中口服剂型由于吸收迅速、生物利用度高、使用方便、安全性高以及日治疗费用相对针剂更经济等诸多优势,广泛用于深部真菌感染的预防及治疗(包括序贯治疗、初始治疗)中。伏立康唑的临床应用疗效受药物相互作用、血药浓度等诸多因素的影响。因此,.

Voriconazole has been extensively applied in clinical treatment of serious fungal infections caused by Aspergillus,Candida,etc.Oral voriconazole has received extensive attention from clinicians and has been used widely for its high bioabsorbability,rapid absorption and convenient in use.However,it is still a problem the clinicians currently explored that how to apply the oral voriconazole well to achieve the target of effective,safe and economical antifungal treatment.The evidence-based recommendations of oral voriconazole application are reviewed to provide clinical references.