炎症在骨髓增殖性肿瘤发生与治疗机制中的研究进展

Research progress of inflammation in the pathogenesis and treatment of myeloproliferative neoplasm

骨髓增殖性肿瘤(myeloproliferative neoplasm,MPN)是一组以一系或多系髓细胞(红系、粒系和巨核系)增殖为主要特征的克隆性造血干细胞肿瘤,按照Bcr-abl融合基因的检测结果,可将其分为两大类:Bcr-abl阳性的慢性髓系白血病和Bcr-abl阴性的MPN[1]。经典的Bcr-abl阴性MPN主要包括真性红细胞增多症(polycythemia vera,PV)、原发性血小板增多症(essential thrombocythemia,ET)和原发性骨髓纤维化(primarymyelofibrosis,PMF)三种类型〔2-3〕。晚期骨髓纤维化阶段,PMF患者会出现输血依赖性贫血、脾大,白细胞增多,约有20%的PMF患者会向终末期急性白血病转化。

Myeloproliferative neoplasm(MPN)is a kind of clone hematopoietic stem cell disease,classical BCR-ABL negative MPN includes polycythemia vera(PV),essential thrombocythemia(ET)and primary myelofibrosis(PMF).Recent advances in molecular biology have greatly facilitated the diagnosis and treatment of MPN.Chronic inflammation has long been associated with MPN disease and some of the symptoms and complications are linked to inflammation.The aim of this paper is to review the research progress of inflammation in the pathogenesis and treatment of MPN.