苦碟子注射液临床用药实效研究

Research on the effectiveness of clinical medication of Kudiezi injection

目的:了解苦碟子注射液的临床应用情况,为其临床规范使用提供参考信息。方法:随机选取我院2012年4月~2013年12月使用苦碟子注射液的患者200例,运用统计描述方法对适应症、用药疗程、用法用量、溶媒、不良反应等信息进行全面分析。结果:使用苦碟子注射液的患者,男女比例近似为1:1,主要来自儿科、针灸康复科、内分泌科、老年病科,临床上主要用于治疗高血压、糖尿病、过敏性紫癜、冠心病、脑梗死;给药途径以静脉滴注为主,单次用药剂量以10~40 m L为多,用药疗程以1~7 d最多,溶媒以0.9%氯化钠和5%葡萄糖注射液多见;合并用药主要有维生素C、小牛血清去蛋白、更昔洛韦、西咪替丁、地塞米松、天麻素;共发生2例不良反应,临床表现为心慌、心累、皮疹。结论:苦碟子注射液临床使用大多符合药品说明书,如适应症、中医证型、单次剂量、溶媒、疗程,但仍有超说明书使用情况存在。要较为全面的了解苦碟子注射液适应病证及用药特征,应继续进行多中心、大样本的研究。

Objective: To investigate the clinical application of Kudiezi injection, and provide reference information for its clinical standard use. Method: 200 cases of patients treated with Kudiezi injection from 2012 April to 2013 December were randomly selected in our hospital. Statistical description method was used to conduct a comprehensive analysis of indications, treatment time, usage, dosage, solvent, adverse reactions and other information. Result: There was a gender balance in patients who were treated with Kudiezi injection. Kudiezi injection was used mostly in department of pediatrics, acupuncture and rehabilitation department, endocrinology, department of geriatrics. And it was mainly used in the clinical treatment of hypertension, diabetes, allergic purpura, coronary heart disease and cerebral infarction. The main administration route was intravenous drip. The dosage of Kudiezi was between 10 to 40 m L and treating time was from 1 to 7 days. The solvent was mainly 0.9% sodium chloride and 5% glucose injection. Concomitant medications were vitamin C, deproteinized calf serum, ganciclovir, cimetidine, dexamethasone, gastrodin. There were two reports of adverse reactions with clinical manifestations of palpitation, heart tired, skin rash. Conclusion: The clinical use of Kudiezi injection are mostly in accordance with drug instructions, including indications, TCM syndrome type, single dose, solvent, and treatment time etc. But there are still some dosage given over the instructions. To more fully understand Kudiezi injection adaptation syndromes and medication characteristics, multi center, large sample research should be conducted.