摘要
目的:考察青黛是否具有胃肠毒性。方法:观察单次给予青黛对正常小鼠肠推进,胃排空及排便的影响。结果:1g.kg-1青黛(相当于临床剂量20倍),可促进正常小鼠的肠推进及排便(P<0.05,P<0.01),对小鼠胃排空有促进趋势,但无统计学意义(p>0.05)。结论:青黛可能存在一定的胃肠毒性,但具体机理未知,还需进一步试验验证。
Objective: To investigate the gastrointestinal toxicity of Qingdai. Method: To observe the effect of Qingdai on intestinal propulsion, gastric emptying and defecation in normal mice after single administration. Result: 1g/kg indigo(equivalent to 20 times of clinical dose) can promote intestinal propulsion and defecation of normal mice(P <0.05 or P <0.01). A tendency of promotion of gastric emptying can be observed with no statistical significance(p>0.05). Conclusion: Qingdai may have certain gastrointestinal toxicity, but the mechanism is unknown which need further experimental verification.
出处
《中药与临床》
2015年第4期12-13,42,共3页
Pharmacy and Clinics of Chinese Materia Medica
基金
成都中医药大学校基金项目:青黛胃肠道毒性研究(编号:ZRMS201333)
关键词
青黛
胃肠毒性
单次给药
Qingdai
gastrointestinal toxicity
single administration
