摘要
目的:考察藏药江孜沙棘对急性血瘀证大鼠血液流变学的影响。方法:60只大鼠随机均匀分为空白对照组,模型对照组,复方丹参滴丸组,江孜沙棘低、中、高剂量组。预防性灌胃给药,每天1次,连续给药8天后,除空白对照组外,其余大鼠均采用颈部皮下注射盐酸肾上腺素复加冰水浴的方法复制大鼠急性血瘀模型;腹主动脉采血,运用SA-6000自动血流变测试仪检测各组大鼠的血液流变学指标。结果:与空白对照组比较,模型对照组大鼠血液流变学指标具有显著性差异(P<0.01或0.05);而江孜沙棘低、中、高剂量组均可使急性血瘀证模型大鼠的全血黏度、红细胞聚集指数等指标降至正常水平以下。结论:江孜沙棘可改善急性血瘀证大鼠血液流变学的异常,证明了藏医药经典著作《晶珠本草》中所记载沙棘具有"益血"的功效。
Objective:The main objective is to observe the effects of Jiangzishaji on hemorheology of rat with acute blood stasis.Method:Sixty rat were divided randomly into blank control group,model control group,compound Danshen dripping pills group,low dose group,middle dose group and high dose group of Jiangzishaji.The rats were orally administered with drugs once a day for 8 days.After the eighth day,the acute blood stasis was induced by subcutaneous injection of adrenaline hydrochloride and ice-water for rats except blank control group.Then blood was collected from abdominal aorta of rats and blood rheology index was detected using SA-6000 automatic blood rheology test apparatus.Result:Compared with blank control group,the hemorheological parameters of model group was significantly different(P<0.01 or 0.05).However,the low,middle and high dose Jiangzishaji decreased the viscosity of whole blood and erythrocyte aggregation and other index of rats with acute blood stasis to less than normal.Conclusion:Jiangzishaji treat the abnormal hemorheology in rats with acute blood stasis and prove that Jiangzishaji has 'beneficial blood' effect recorded in the Tibetan medical classics 'Jing-Zhu Materia Medica'.
出处
《中药与临床》
2016年第5期35-37,41,共4页
Pharmacy and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(81473428)
关键词
藏药
江孜沙棘
急性血瘀证
血液流变学
Tibetan medicine
Jiangzishaji
acute blood stasis
hemorheology
