“药材-提取物-成分”追踪附子强心作用物质基础

Exploration of the material basis for cardiotonic effect of Fuzi under the guidance “Herb-Extract-Ingredient”

按照药材-提取物-成分逐层跟踪的思路,分析总结国内外有关附子不同成分的强心作用及其与量-毒-效关系的研究文献,发现附子的强心作用成分主要为水溶性成分,包括去甲乌药碱、去甲猪毛菜碱、氯化甲基多巴胺等水溶性生物碱及附子苷、尿嘧啶等非生物碱。其强心作用主要通过上述成分增加左心室收缩压(LVSP)和左心室收缩压力上升最大速率(LVd P/dt max)及降低左心室收缩压力下降最大速率(-LVd P/dt max)实现。

In accordance with the guidance of 'Herb-Extract-Ingredients',literatures related to the cardiotonic effect of different components in Fuzi and dose-toxicity-effect relationship of Fuzi at home and abroad were analyzed and summarized in the study.The cardiotonic effect was mainly caused by water-soluble components in Fuzi,including water-soluble alkaloids such as higenamine,salsolinol,methyl chloride,and non-alkaloids such as fuzinoside and uracil,and so on.The left ventricular systolic pressure(LVSP) and maximal rate of the increase of left ventricular pressure(LVd P/dt max) were increased,and the maximal rate of the decrease of left ventricular pressure(-LVd P/dt max) was reduced by the above ingredients to achieve the cardiotonic effect.