重庆地区绝经妇女骨质疏松症与维生素D受体基因多态性的关系

Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women

目的 探讨在重庆市区生活 10年以上的汉族绝经妇女骨质疏松症与维生素D受体基因多态性的关系。方法 用聚合酶链反应 限制性片段长度多态性技术检测了 40例绝经后患骨质疏松症的妇女和 2 1名同龄绝经后无骨质疏松症的妇女的维生素D受体基因多态性。结果 骨质疏松组维生素D受体基因型bb、Bb、BB频率分别为 82 .5 %、17.5 %及 0 ,无骨质疏松组分别为 85 .71%、14 .2 9%及 0 ,两组差异无显著性 (P >0 .0 5 )。结论 就目前调查例数看 ,重庆地区汉族妇女骨质疏松与BB基因型无明显相关性。

Objective: To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women. Methods: The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women. Results: In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85. 71%, 14.29% and 0, respectively (P>0.05). Conclusion: Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.