三七对严重烫伤大鼠肝组织脂质过氧化影响的探讨

STUDIES OF THE AFFECTION ON LIPID-PEROXIDATION FROM LIVER TISSUE IN SCALDED RAT BY PANAX NOTOGINSENG

目的 :探讨三七对烫伤大鼠肝组织脂质过氧化的影响及保护作用。方法 :采用大鼠 4 0 %体表面积 (TB SA)Ⅲ度烫伤模型 ,通过检测大鼠严重烫伤后肝组织内丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GSH -PX)和超氧化物歧化酶 (SOD)的改变 ,观察三七对烫伤大鼠的保护作用。结果 :4 0 %TBSAⅢ度烫伤后大鼠肝组织内MDA显著升高 ,GSH -PX和SOD活力显著降低 ,三七治疗组大鼠肝组织内MDA含量显著降低 ,GSH -PX和SOD活力显著升高 ,与单烫伤组比较各指标均有显著性差异。结论 :烫伤后肝组织内脂质过氧化增强 ,抗氧化能力减弱 ,三七具有较强的抗氧化、抗自由基损伤的保护作用。

Objective:To study the affection and protection for lipid-peroxidation from liver tissue in scalded rats by panax notoginseng. Methods:Using 40% TBSA Ⅲ degree scalded rat mode, studying the changes of MDA; GSH-PX and SOD in liver tissues to study the protection by Panax notoginseng. Results:The result showed that 40% TBSA Ⅲ degree empyrosis resulted in significant increase of MDA and obvious decreases of GSH-PX and SOD activity in liver tissues. The amount of MDA was decreased significantly and the GSH-PX and SOD were activity increased apparently after the treatment of Panax notoginseng. There were statistical differences of these indexes between the two groups. Conclusion: It was suggested that there were strong lipid-peroxidation and decreased antioxidation in the liver tissue after empyrosis, relatively, Panax notoginseng, had strong function of antioxidation and free radical seanvenging.