脑肿瘤患者脑脊液中β_2微球蛋白和β-葡萄糖醛酸酶同步测定的临床意义

Clinical Significance of Synchronous Detection of β_2-microglubin and β-glucuronidase in CSF of Patients With Cerebral Tumor

目的 探讨脑肿瘤患者脑脊液中 β2 微球蛋白和 β -葡萄糖醛酸酶 ( β -G)活性测定的临床意义。 方法 分别采用放免法和ELISA技术测定脑肿瘤及非肿瘤脑病患者脑脊液中 β2 微球蛋白和 β -G活性。 结果 恶性脑瘤患者脑脊液中无论 β2 微球蛋白和 β -G活性均明显高于良性脑瘤和头痛患者 ,分别为 P <0 0 5和P <0 0 1;且恶性脑瘤患者脑脊液中两者增高程度呈正相关 ,但与肿瘤大小、恶性程度无关 ;其中恶性脑瘤患者脑脊液中 β -G活性术后呈下降趋势。 结论 脑脊液中 β2 微球蛋白和 β -G活性测定对恶性脑肿瘤诊断有一定的辅助参考价值 ;β -G活性测定对恶性脑肿瘤病程判定有一定临床意义。

Objective To study the clinical significance of the content of β 2-microglubin and activity of β-glucuronidase in cerebrospinal fluid (CSF) of patients with cerebral tumor. Methods The activities of β 2-microglubin and β-glucuronidase in CSF of patients with cerebral tumor and non- cerebral tumor were analyzed by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) respectively. Results the activities of β 2-microglubin and β-glucuronidase in cerebral malignancy were obviously higher than that of cerebral benign tumor (P<0 05),and headache patients (P<0 01); the degree of raise of both the activities in cerebral malignancy was positively correlated,however,it wasn't related to the size and the degree of malignancy; the activity of β-glucuronidase in CSF of patients with cerebral malignancy was assumed descendant tendency after operation.Conclusions The content of β 2-microglubin and activity of β-glucuronidase in CSF is helpful to diagnose cerebral malignancy;β 2-microglubin content and the activity of β-glucuronidase could indicate course of disease and have clinical significance for the cerebral malignant cases.