摘要
以芳香醛与苯乙酮为原料,Na OH为催化剂,在水相中合成了一系列查尔酮化合物。在超声辅助下,研究了混合碱(Na OH-Na_2CO_3)催化查尔酮与三乙(乙酰乙酸乙酯)的Michael加成反应,合成了一系列Michael加成产物,并对影响反应的因素进行了探究,得出最佳反应条件为:40oC下,在PEG-400/H_2O介质中,n_(查尔酮)/n_(三乙)=1/1.5,n_(Na OH)/n_Na_2CO_3)=1/1.5,得到目标产物的产率最好,高达91.2%。此方法操作简单,反应时间短,产率高。
A series of chalcones are synthesized from aromatic aldehyde and acetophenone,with H_2 O as the solvent and sodium hydroxide as the catalyst. A series of Michael addition products are obtained from these chalcones and ethyl acetoacetate,catalyzed by sodium hydroxide and anhydrous sodium carbonate under the assistance of ultrasonic irradiation. And the inflences of the addition reaction condition on the yield are studied. The premium condition are determined by followings: the molar ratio of chalcone and ethyl acetoacetate is 1 /1. 5,sodium hydroxide / anhydrous sodium carbonate is 1 /1. 5 under PEG- 400 /H_2 O in 40 oC,the desired product is obtained,and the yield can be up to 91. 2%. The method of this synthesis has advantages such as simple to operate,short reaction time and high yield.
出处
《陇东学院学报》
2016年第3期41-45,共5页
Journal of Longdong University
基金
甘肃省应用化学省级重点学科建设项目资助(GSACKS20130113)
