胸腺肽α1在长期机械通气患者预防呼吸机相关肺炎的应用

Prevention of Ventilator-associated Pneumonia in the Patient with Longer Mechanical Ventilation Using Thymosin α1 (Zadaxin)

目的 分析胸腺肽 α1(日达仙 )在长期机械通气患者预防呼吸机相关肺炎的应用价值。方法 对 1例高龄长期应用机械通气患者给予胸腺肽 α11.6 mg,皮下注射 ,每周两次 ,治疗 1年余 ,分析应用胸腺肽 α1后 0 .5年及0 .5～ 1年时间内与未应用胸腺肽 α1两个 0 .5年时间的体温变化、肺部感染次数、痰培养结果及病重、病危天数、药费、检查费等 ,并对血常规、血生化结果进行比较。结果 应用胸腺肽 α1后体温升高天数减少 ;呼吸机相关肺炎发生次数减少 ;对抗生素不敏感的嗜麦芽寡养单胞菌消失 ,各项检查次数减少 ,血尿素氮恢复正常 ,病情处于平稳状态。结论 长期机械通气患者应用胸腺肽 α1治疗可减少呼吸机相关肺炎次数 ,改善患者全身状况 ,减少医疗费用。

OBJECTIVE To analyse the values in prevention of ventilator associated pneumonia in the patient with longer mechanical ventilation using thymosin α1 (Zadaxin). METHODS The elder patient with longer mechanical ventilation, was subcutaneously administering thymosin α1, 1.6mg, 2 times per week for more than one year, and the changes in temperature of the patient, times duration of ventilator associated pneumonia, results in culture of sputum, fee expense for medicine, fee expense for examination, days of critical condition of the patient before and after drug use were analysed. RESULTS Days with more than 37℃ were diminuted, the times duration of ventilator associated pneumonia were decreased, Stenotrophomonas maltophilia in culture of sputum was disappeared, fee expense for medicine and fee expense for examination were descented, days of critical condition of the patient were decreased, blood urea nitrogen(BUN) reconverted normally after using thymosin α1. CONCLUSIONS Thymosin α1 can decrease times duration of ventilator associated pneumonia, improve general condition of the patient, minimize fee expenses for medicine and examination.